IMMUNE CHECKPOINT INHIBITORS AS THE SECOND-LINE TREATMENT FOR ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A COST-EFFECTIVENESS ANALYSIS BASED ON NETWORK META-ANALYSIS

Abstract Background Immune checkpoint inhibitors (ICIs) have demonstrated superior clinical efficacy in prolonging overall survival (OS) as the second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), and were recommended by the guidelines.However, it remains uncertain which ICI is the most cost-effective.This stu

A method for improving radar-derived quantitative precipitation estimation is proposed.Tropical vertical profiles of reflectivity (VPRs) are first determined from multiple VPRs.Upon identifying a tropical VPR, the event can be further classified as either tropical-stratiform or tropical-convective rainfall by a fuzzy logic (FL) algorithm.Based on t

Background/Objectives: HIV-associated neurocognitive impairment (NCI) remains a prevalent issue among people with HIV (PWH) despite Inlet Hose advancements in antiretroviral therapy (ART).The pathogenesis of HIV-associated NCI is linked to chronic neuroinflammation caused by HIV, even in those with successful viral suppression.Growth Differentiatio

A cultural infrastructure of shared morality is Lubricants necessary for the success of market economics.Traditional views maintain that religion is the nurturing source of the morality, which grows in the culture.The Progressive revolution aims to overturn Traditional morality and impose its social justice morality on culture.This article dissects